The tumor dependency oncology research approach involves identifying and targeting mechanisms and dependencies that are unique to malignant tumors.1 This area of research and development has produced novel targeted therapies which may address one or more of the biological hallmarks of cancer which tumors exploit to proliferate, such as, resisting cell death (avoiding apoptosis) sustaining proliferative signaling, evading growth suppressors, enabling replicative immortality.1
The ability of tumor cell populations to expand in number is determined not only by the rate of cell proliferation (cell replication) but also by the rate of cell attrition (cell death):1
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