The bromodomain and extraterminal (BET) proteins are a bromodomain subfamily that includes BRD2, BRD3, BRD4, and BRDT.1
The BET proteins utilize bromodomains to interact with acetylated histone tails and mediate downstream functions, such as histone acetylation recognition, chromatin remodeling, and transcription regulation.1,5
BET family proteins are involved in promoting aberrant oncogene expression in a variety of cancers.7-10
Overexpression and gain-of-function mutations of BET proteins can alter gene transcription, histone modification, DNA repair, and apoptosis.1
BRD4 is implicated in a number of hematological and solid tumors.11
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