The B-cell lymphoma 2 (BCL-2) family is composed of anti- and pro-apoptotic proteins that function to regulate the intrinsic pathway of apoptosis, or programmed cell death, and help maintain tissue homeostasis.1,2
The BCL-2 family is composed of anti- and pro-apoptotic proteins that function to regulate the intrinsic pathway of apoptosis.1,2
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP), a process leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.6
Acquired resistance to apoptosis is a hallmark of most, if not all types of cancer.7
Overexpression of anti-apoptotic BCL-2 family proteins (BCL-2, BCL-XL, BFL-1/A1, BCL-W and MCL-1) disrupts the dynamic balance of anti- and pro-apoptotic proteins, which may promote cancer cell survival.2,5
Strategies to inhibit anti-apoptotic BCL-2 proteins include reducing protein expression by targeting the corresponding mRNA with an antisense oligonucleotide as well as blocking anti-apoptotic activity by targeting at the protein level.2,5
The majority of tumors have defects in the p53 pathway and many overexpress BCL-2 or a close relative, such as BCL-XL.2
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