There are many natural immune effector mechanisms for tumor detection and elimination.1 Regular function of these mechanisms helps prevent tumor growth and metastasis.
The discovery and development of immuno-oncology therapy in recent years represents a milestone in the treatment of cancer. However, treatment challenges persist. The potential to address a range of additional immune checkpoint biomarkers makes continued research in immuno-oncology vital to the evolution of cancer therapy.
Suppression, evasion, and appropriation of natural immune effector mechanisms for tumor detection and elimination contribute to tumor growth and metastasis.
The introduction of immune checkpoint inhibitors in oncology has increased the potential for durable responses and shifted therapeutic attention to extending the tail of the survival curve. However, not all patients respond to currently available immunotherapy agents.
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