We are exploring the potential of dual-targeted single agents. Bispecific antibodies (bsAbs) are engineered to recognize two different antigens or epitopes at the same time.1 These are also referred to as dual-specificity antibodies.1
The versatility of bispecific antibodies introduces a wide range of potential applications.1
Dual-Variable-Domain Immunoglobulins (DVD-IgTM)
A DVD-Ig combines the target-binding variable domains of two monoclonal antibodies, fused in tandem via naturally occurring or glycineâˆ’serine linkers to create a tetravalent, dual-targeting single agent.2,3
Formats based on single-chain variable fragments (scFv)
ScFv-based bsAbs are fusions of only the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide.1
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