PRLR is a type I cytokine transmembrane receptor expressed on the surface of many cell types, including breast epithelial cells.1
PRLR and its ligand, the peptide hormone prolactin (PRL), are classically recognized for their role in mammary gland development and lactation.1
Binding of PRL to PRLR activates the Jak/Stat5, Ras/Raf/MAPK, PI3K/Akt, and Rac pathways.1
Epidemiological data and preclinical studies suggest a role for PRLR in pathogenesis of breast cancer.
PRLR is also frequently expressed at high levels in other cancers5,6
PRLR antagonists have been shown to inhibit proliferation of breast cancer cells in vitro and inhibit tumor growth in rodent models in vivo.7,8
The site you have requested is intended to provide information for healthcare professionals residing in the US or Puerto Rico.
I am a licensed healthcare professional residing in the US or Puerto Rico.
I am not a licensed healthcare professional residing in the US or Puerto Rico.
Contact Medical Information
For All Other Information