Mesothelin (MSLN) is a 40-kDa plasma membrane-bound glycoprotein whose normal biologic role is unclear.1,2
Overexpression of MSLN induces malignant transformation and aggressiveness by promoting cancer cell proliferation, contributing to local invasion and metastasis, and conferring resistance to apoptosis induced by cytotoxic agents.4-7
Upregulated MSLN plays a key role in controlling epithelial-to-mesenchymal transition (EMT) and inducing stem cell properties in human lung cancer and mesothelioma cells.4
MSLN is expressed at a high level in almost all mesothelioma and many other solid tumors.8,9
MSLN expression is more prevalent in aggressive histologic subtypes of lung (KRAS+ tumors),7 breast (triple-negative),5 and esophageal cancers (high-grade dysplasia and adenocarcinoma).16
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