DLL4 is a cell-surface ligand that activates the Notch 1 receptor and performs critical functions in both normal vascular development and pathological angiogenesis.1
DLL4/Notch is a distinct angiogenic pathway from VEGF/VEGFR.2 The VEGF/VEGFR and DLL4/Notch signaling pathways function in coordination to regulate normal and pathological angiogenesis, blood vessel differentiation, and homeostasis.3 DLL4 has also been observed to interact with other VEGF-dependent and -independent pathways.4-7
In addition to tumor angiogenesis, DLL4 has also been shown to play a role in the maintenance of tumor-initiating cells or cancer stem cells (CSCs) and chemoresistance.1,8-10
The site you have requested is intended to provide information for healthcare professionals residing in the US or Puerto Rico.
I am a licensed healthcare professional residing in the US or Puerto Rico.
I am not a licensed healthcare professional residing in the US or Puerto Rico.
Contact Medical Information
For All Other Information