Cancer stem cells (CSCs) are the "roots" of a tumor. Also known as tumor initiating cells (TICs), CSCs represent a small subpopulation of the tumor that initiates and perpetuates tumor growth. CSCs give rise to various differentiated progeny that make up the bulk of the rapidly dividing tumor.1,2
"Stemness" features of CSCs1-4:
CSCs sustain cancer survival and progression.
Strategies aimed at eliminating CSCs include targeting specific surface markers, sensitizing CSCs to therapy, and modulating "stemness" signaling pathways.3,4
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